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Upstream Bio Announces $200M Series B Financing To Advance Upb-101 For Allergic And Inflammatory Diseases

PUBLIC · UPBJun 08, 2023

Amount Raised

$200 Million

Round Type

Series B

WalthamBiotechnologyHealth CareScience And Engineering

Investors

Alex RosenSamsara Bio CapitalOmega FundsHBM Healthcare InvestmentsTcg XAltshuler Shaham Provident Funds Ltd.Decheng CapitalAccess BiotechnologyOrbi MedWellington ManagementBain Capital Life SciencesVenrock Healthcare Capital PartnersEnavate Sciences

Description

Upstream Bio, a clinical-stage biotech company advancing new therapies to treat inflammation, today announced the completion of a $200 million Series B financing. The Series B round was led jointly by Enavate Sciences and Venrock Healthcare Capital Partners, with participation from other new investors Bain Capital Life Sciences and Wellington Management and Series A investors OrbiMed, Access Biotechnology, Decheng Capital, Altshuler Shaham Provident Funds Ltd., TCG X, HBM Healthcare Investments, Omega Funds and Samsara BioCapital.

Quick answer

Upstream Bio raised $200 Million in a Series B round, dated June 8, 2023. Investors: Alex Rosen, Samsara Bio Capital, Omega Funds, HBM Healthcare Investments, Tcg X, Altshuler Shaham Provident Funds Ltd., Decheng Capital and Access Biotechnology. Upstream Bio is based in Waltham, Massachusetts, United States.

How much did Upstream Bio raise?
Upstream Bio raised $200 Million in a Series B round on June 8, 2023.
Who invested in Upstream Bio?
Alex Rosen, Samsara Bio Capital, Omega Funds, HBM Healthcare Investments, Tcg X, Altshuler Shaham Provident Funds Ltd., Decheng Capital and Access Biotechnology are named as investors in this round.
What does Upstream Bio do?
At Upstream Bio we strive to reach the source of inflammation and conquer it.
Where is Upstream Bio based and how big is it?
Upstream Bio is based in Waltham, Massachusetts, United States. Fundz records about 75 employees.
Who are the decision-makers at Upstream Bio?
Fundz holds 1 contact at Upstream Bio. Names and contact details are shown to Fundz members.

Source: Fundz verified event record.

Who else raised in Science And Engineering and Biotechnology around the same time

Companies in the same sectors as Upstream Bio that raised within 45 days of this round, from Fundz verified event records.

  • RedHill Biopharma Ltd raised $2.7M (Seed) on July 21, 2023.
  • Septerna raised $73M on June 28, 2023.
  • Feldan Therapeutics raised $17M (Series B) on June 13, 2023.
  • Ray Therapeutics raised $14M on May 15, 2023.
  • Hubly raised $3M (Seed) on July 21, 2023.
  • SURGE Therapeutics raised $32M (Series B) on July 19, 2023.

Who to call at Upstream Bio, and when

A new round usually means Upstream Bio is about to hire and buy. The teams that reach out first get the meeting.

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Company Information

Company

Upstream Bio

Location

890 Winter Street, Suite 200

Waltham, Massachusetts, United States

About

At Upstream Bio we strive to reach the source of inflammation and conquer it. Our lead program is a clinical-stage monoclonal antibody that inhibits the TSLP receptor. TSLP is a validated target positioned upstream of multiple signaling cascades that affect a variety of immune cells pivotal to common and rare diseases. We are leveraging our diverse roots and the team’s substantial industry experience to develop therapies that ease the burden of inflammatory and allergic diseases on patients and their loved ones. https://www.upstreambio.com/

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Funding Insights

What this usually means
Timeline to next round
Series B companies typically work for 15-20 months before raising new capital
Growth expectations
Series B companies are expected to scale rapidly and expand market reach

Upstream Bio raised. Fundz records a round at a median of 3.6 minutes from the SEC filing, with the decision-maker attached.

145 of these a day, filtered to the companies you pick, with the decision-maker attached.

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Fundz is a real-time business intelligence platform powered by agentic AI that proactively delivers personalized daily signals, including funding rounds, executive changes, M&A activity, 13F institutional filings, SEC 8-K events, investor activity, and website modifications, based on each user's watchlist and ICP. A trusted data source at firms such as BlackRock, Oracle, Kleiner Perkins, LinkedIn, HubSpot, and Cloudflare, Fundz democratizes the institutional-grade intelligence that previously required a PitchBook or Bloomberg terminal. Features include Daily Briefing for AI-powered daily briefings, and unified cross-signal alerts across 281,000+ organizations. Developers and data teams can access these signals programmatically via the Fundz Funding Data API, with transparent published pricing.