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Spyre Therapeutics has priced a $275 million public offering of common stock at $18.50 per share, expected to close on October 15, 2025. Jefferies LLC and other firms are leading the offering.

PUBLIC · SYREOct 14, 2025

Amount Raised

$275 Million

Round Type

Post-IPO Equity

WalthamBiotechnologyHealth CareTherapeutics

Investors

Wedbush Securities Inc.Stifel, Nicolaus & Company, IncorporatedLeerink Partners LLCTD Securities (USA) LLCJefferies LLC

Description

Spyre Therapeutics, Inc. announced the pricing of its underwritten public offering of 14,864,865 shares at $18.50 per share, expected to raise approximately $275 million. The offering's lead managers include Jefferies LLC and Stifel, Nicolaus & Company. The company has granted underwriters a 30-day option to purchase additional shares

Quick answer

Spyre Therapeutics raised $275 Million in a Post-IPO Equity round, dated October 14, 2025. Investors: Wedbush Securities Inc., Stifel, Nicolaus & Company, Incorporated, Leerink Partners LLC, TD Securities (USA) LLC and Jefferies LLC. Spyre Therapeutics is based in Waltham, Massachusetts, United States.

How much did Spyre Therapeutics raise?
Spyre Therapeutics raised $275 Million in a Post-IPO Equity round on October 14, 2025.
Who invested in Spyre Therapeutics?
Wedbush Securities Inc., Stifel, Nicolaus & Company, Incorporated, Leerink Partners LLC, TD Securities (USA) LLC and Jefferies LLC are named as investors in this round.
What does Spyre Therapeutics do?
Spyre Therapeutics is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases.
Where is Spyre Therapeutics based and how big is it?
Spyre Therapeutics is based in Waltham, Massachusetts, United States. Fundz records about 112 employees.
Who are the decision-makers at Spyre Therapeutics?
Fundz holds 1 contact at Spyre Therapeutics. Names and contact details are shown to Fundz members.

Source: Fundz verified event record.

Who else raised in Therapeutics and Biotechnology around the same time

Companies in the same sectors as Spyre Therapeutics that raised within 45 days of this round, from Fundz verified event records.

  • Azora Therapeutics, Inc. (DE) raised $4.3M on November 28, 2025.
  • SymPhysis Medical raised $1.3M (Grant) on November 26, 2025.
  • Verrica raised $50M on November 25, 2025.
  • FibroBiologics raised $1.5M on November 24, 2025.
  • MindImmune Therapeutics raised $10M (Series A) on November 24, 2025.
  • BeyondSpring raised $2M (Funding Round) on November 21, 2025.

Who to call at Spyre Therapeutics, and when

A new round usually means Spyre Therapeutics is about to hire and buy. The teams that reach out first get the meeting.

  • An alert the day Spyre Therapeutics raises, hires an executive or expands, scored against what you sell
  • The decision-makers there, with verified emails
  • Who you already know at Spyre Therapeutics, from your own LinkedIn network

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Company Information

Company

Spyre Therapeutics

Location

221 Crescent Street

Waltham, Massachusetts, United States

About

Spyre Therapeutics is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.

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Spyre Therapeutics raised. Fundz records a round at a median of 3.6 minutes from the SEC filing, with the decision-maker attached.

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Fundz is a real-time business intelligence platform powered by agentic AI that proactively delivers personalized daily signals, including funding rounds, executive changes, M&A activity, 13F institutional filings, SEC 8-K events, investor activity, and website modifications, based on each user's watchlist and ICP. A trusted data source at firms such as BlackRock, Oracle, Kleiner Perkins, LinkedIn, HubSpot, and Cloudflare, Fundz democratizes the institutional-grade intelligence that previously required a PitchBook or Bloomberg terminal. Features include Daily Briefing for AI-powered daily briefings, and unified cross-signal alerts across 281,000+ organizations. Developers and data teams can access these signals programmatically via the Fundz Funding Data API, with transparent published pricing.