Pretzel Therapeutics Launches With $72.5 Million Series A Financing To Pioneer Mitochondrial Therapies

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Pretzel Therapeutics is on a mission to develop groundbreaking therapies to reverse mitochondrial dysfunction by leveraging a deep mechanistic understanding of mitochondrial biology. Mitochondria are essential energy-converting organelles found in nearly every cell type throughout the body, and their dysfunction is implicated in more than 50 diseases. The most severe of these, known collectively as mitochondrial diseases, are rare genetic conditions that can affect individuals of all ages. Mitochondrial dysfunction also plays a key role in more common conditions, including aging-related disorders. We are creating first-in-class therapeutics that target mitochondrial dysfunction at its roots by addressing its genetic drivers—an approach we believe could be effective across a wide range of diseases that currently lack meaningful treatment options.