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Epicrispr Biotechnologies closed a $90 million Series C financing round, led by Octagon Capital and Janus Henderson Investors, to push EPI-321 into pivotal trials.

PRIVATEAug 10, 2026about 3 hours ago

Amount Raised

$90 Million

Round Type

Series C

San FranciscoBiotechnologyHealth CareGeneticsTherapeutics

Investors

Readout CapitalAngelini VenturesAbrdn Inc.Sanofi VenturesDuquesne Family OfficeCormorant Asset ManagementFidelity Management & Research CompanyJanus Henderson InvestorsOctagon Capital

Description

Epicrispr Biotechnologies has secured a $90 million Series C financing round, oversubscribed and supported by a notable array of investors including Fidelity and Sanofi Ventures. This funding will focus on advancing EPI-321, its lead candidate for treating facioscapulohumeral muscular dystrophy, through pivotal clinical development. The company aims to demonstrate that gene silencing can become a viable therapeutic option without altering DNA. This significant investment reflects growing confidence in epigenetics as a therapeutic modality.

Company Information

Company

Epicrispr Biotechnologies

Location

San Francisco, California, United States

About

Epicrispr Biotechnologies is a biotechnology company focused on developing curative therapies for genetic neuromuscular diseases. Their lead program, EPI-321, is a first-in-class disease-modifying therapy for facioscapulohumeral muscular dystrophy (FSHD). The company aims to advance innovative treatments that address the underlying causes of genetic disorders. With recent funding, Epicrispr is entering the clinical stage to bring much-needed therapies to patients.

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