Ratio Enters License and Collaboration Agreement with Novartis for SSTR2-targeting Radiotherapeutic Candidate

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Ratio Therapeutics Inc. is a clinical-stage pharmaceutical company with the mission to accelerate the development of next-generation precision radiopharmaceuticals for solid tumors and transform oncology treatment paradigms. With headquarters and laboratories in Boston, the company currently employs a growing team of multidisciplinary experts with backgrounds in radiopharmaceutical discovery and development. Ratio's proprietary R&D platforms, Trillium™ and Macropa™, enable the development of fit-for-purpose radiopharmaceuticals for therapy and imaging that possess pharmacokinetic modulation, thereby improving drug availability, tumor delivery, and tumor loading. The company maintains a strong commitment to manufacturing through its collaboration with PharmaLogic and its own state-of-the-art facility located in Salt Lake City, Utah, ensuring reliable supply and quality in radiopharmaceutical production. Ratio plans to initiate a Phase 1/2 trial to evaluate the safety, tolerability and efficacy of its FAP-targeted radiotherapeutic as a treatment for patients with relapsed or refractory soft tissue sarcoma. The company is also advancing other programs in its pipeline, including the pre-clinical assessment of [Lu-177]-RTX2358 across several cancer indications to explore its broader therapeutic potential and expects its Granzyme B-targeted agent for PET imaging program to move into the clinic in 2026.