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Arrowhead Pharmaceuticals and Sarepta Therapeutics Sign Global License and Collaboration Agreement for Multiple Clinical and Preclinical Programs

Nov 26, 2024over 1 year ago

Contract Type

agreement

PasadenaManufacturing

Description

Arrowhead Pharmaceuticals, Inc. has announced a global licensing and collaboration agreement with Sarepta Therapeutics, involving an upfront payment of $825 million, cash and equity investments, along with potential future milestone payments and royalties on commercial sales. The agreement encompasses multiple clinical and preclinical programs in rare, genetic diseases of the muscle, central nervous system (CNS), and the lungs, extending Arrowhead's cash runway and potentially leading to new drug launches.

Company Information

Company

Arrowhead

Location

Pasadena, California, United States

About

Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

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