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SutroVax Announces $110M Series D Financing to Advance Broadest-Spectrum Pneumococcal Vaccine Candidates to Prevent Pneumonia

Mar 26, 2020•over 5 years ago

Amount Raised

$110 Million

Round Type

series d

Foster City

Description

SutroVax, a biopharmaceutical company dedicated to the delivery of superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide, today announced the closing of a $110 million Series D preferred stock financing, co-led by new investors RA Capital Management and Janus Henderson Investors. All of SutroVax's existing institutional investors, including TPG Growth, Abingworth, Longitude Capital, Frazier Health Care Partners, Pivotal bioVenture Partners, Medixci, CTI Life Sciences, Roche Venture Fund, and Foresite Capital also participated in the financing.

Company Information

Company

Svx 24

Location

Foster City, California, United States

About

SVX-24 is designed to improve upon the 13-valent PCV standard of care by covering the additional eleven strains that are responsible for the majority of residual pneumococcal disease currently in circulation in both the United States and European Union and associated with high case-fatality rates, antibiotic resistance and/or meningitis. The company believes it can achieve this by employing its cell-free protein synthesis platform, which is comprised of the XpressCFTM platform exclusively licensed from Sutro Biopharma and its proprietary know-how that offers several advantages over conventional cell-based protein expression methods, which the company believes enables it to generate a more broad-spectrum PCV. SutroVax believes it can add more antigenic strains without compromising the overall immune response. In particular, SutroVax's ability to specify the attachment point of antigens, including polysaccharides, on protein carriers represents a significant improvement over the random conjugation that occurs with conventional PCVs. This site-specific conjugation is designed to ensure that T-cell epitopes on the protein carrier are optimally exposed, maximizing the immune response, whereas random conjugation can block these critical immunogenic epitopes, dampening the immune response and causing a phenomenon known as carrier suppression. The company believes this precise control of conjugation chemistry enables it to design broader-spectrum conjugate vaccine candidates using carrier-sparing conjugates that use less protein carrier without sacrificing immunogenicity.

Company News

(1 articles)

Thu, 21 May 2020 07:00:00 GMT

SutroVax Announces Name Change to Vaxcyte - GlobeNewswire

FundzWatch™ Score

Medium Activity

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